Endocrine Abstracts

Homozygous familial hypercholesterolemia (HoFH) represents a potentially fatal condition that is caused by low density lipoprotein (LDL) cholesterol receptor deficiency. Statins alone are not effective in HoFH. In recent years, semiselective or selective LDL cholesterol apheresis systems have been shown to prolong life. However, applying LDLC apheresis therapy, recent evidence also suggests that more intense LDL cholesterol reduction is associated with more clinical benefit. E...

C-reactive protein (CRP) is a non-specific but sensitive marker of underlying systemic inflammation. High CRP levels correlate with risk for future cardiovascular events. Statins can lower the circulating levels of CRP. In contrast, the evidence that fibrates lower CRP levels is very limited. This retrospective study evaluates the effect of micronised fenofibrate on plasma levels of CRP in patients with combined hyperlipidemia.Sixty-four patients with co...

Numerous clinical manifestations have been described in association with Cushing’s disease (CD). There was no eligible data on pulmonary function tests in CD patients. We aimed to assess pulmonary function test included spirometry in a series of patients with active Cushing’s disease (2 men, 9 women). Mean age, height, weight, body mass index were 36.7±12.6 (range 22–63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respective...

Objective: Patients with hyperthyroidism occasionally need rapid restoration to the euthyroid state. In wiew of the increased enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) in thyrotoxicosis, and metabolic effects of konjac glucomannan in gastrointestinal system, we aimed to determine the activity of glucomannan in treatment of hyperthyroidism.Methods: A prospective, randomized, placebo-controlled, one-blind study design was used w...

Combined hyperlipidemia is characterized by elevated levels of total cholesterol, low density lipoprotein (LDL), triglyceride and mild decrease in high density lipoprotein (HDL) cholesterol. It is difficult to achieve desirable decreases of LDL cholesterol, triglycerides and increasing of HDL cholesterol with monotherapy in patients with mixed hyperlipoproteinemia. This retrospective study was carried out to assess the safety atorvastatin-fenofibrate combination therapy.<p...

Polycystic ovary syndrome (PCOS), affects approximately 5% to 10% all women. Insulin resistance is highly associated with this syndrome. Insulin resistance is associated with increased oxidation of low density lipoprotein (LDL) cholesterol. Oxidized LDL autoantibody levels are generally measured to evaluate the degree of LDL oxidation. In the present study, we aimed to measure serum titers of oxidized LDL autoantibodies in patients with PCOS.Twenty-five ...